With advances in the understanding of cellular and molecular signaling transduction in breast cancer, novel biologic therapies that target a variety of signaling pathways have emerged within the last decade. More recently, therapies acting on targets involved in tumor angiogenesis and proliferation in breast cancer have demonstrated positive results, which will lead to changing paradigms in breast cancer treatment. Also, based on positive outcomes of recent clinical trials, targeted therapies are now being employed in the adjuvant setting.ighlighting current research in breast cancer, colorectal cancer, lung cancer, head and neck cancers, and oncology supportive cancer care topics.